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How do external cues, such as growth factors, nutrient availability, and environmental stressors, integrate with intracellular signaling pathways to modulate cell cycle progression, including the

How do external cues, such as growth factors, nutrient availability, and environmental stressors, integrate with intracellular signaling pathways to modulate cell cycle progression, including the induction of cell cycle arrest, DNA damage repair, and apoptotic responses in response to cellular stresses? 

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