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Synthesis of FDG 11911 KOH A B 15 F Deoxyglucose FDG R=20 1. Provide a mechanism for the conversion of A to B 2. Time
Synthesis of FDG 11911 KOH A B 15 F Deoxyglucose "FDG" R=20 1. Provide a mechanism for the conversion of A to B 2. Time is of the essence in radiofluorination reactions. The half-life of 18F is only 110 minutes. This means that the fluoride has 110 minutes from the hospital cyclotron to be injected into the patient before half of the potency is lost. Based on your mechanism, which identity of R would you expect to undergo the displacement by 18F the fastest? Explain your reasoning
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