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The molecule 1, is well known mechanism based inhibitor for one of the PLP containing enzyme. The molecule can adopt either pathway A or B,

The molecule 1, is well known mechanism based inhibitor for one of the PLP containing enzyme. The molecule can adopt either pathway A or B, and can lead to I or II adduct formation. One adduct was formed from 1 covalently linked to pyridoxal 5-phosphate (PLP) (I) while the other adduct was formed with the inhibitor covalently linked to Lysine246, the active site lysine.



co HN HN Lys %3D

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